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Article

The fission yeast Stn1-Ten1 complex limits telomerase activity via its SUMO-interacting motif and promotes telomeres replication.

Science advances - 1 May 2018

Matmati Samah, Vaurs Mélina, Escandell José M, Maestroni Laetitia, Nakamura Toru M, Ferreira Miguel G, Géli Vincent, Coulon Stéphane

Abstract excerpt

Mammalian CST (CTC1-STN1-TEN1) complex fulfills numerous functions including rescue of the stalled replication forks and termination of telomerase action. In fission yeast lacking the CTC1 ortholog, the Stn1-Ten1 complex restricts telomerase action via its sumoylation-mediated interaction with Tpz1TPP1. We identify a small ubiquitin-like modifier (SUMO)-interacting motif (SIM) in the carboxyl-terminal part of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 29774234
DOI: 10.1126/sciadv.aar2740
PMCID: PMC5955624

Genes

CTC1
STN1
TEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The fission yeast Stn1-Ten1 complex limits telomerase activity via its SUMO-interacting motif and promotes telomeres replication.PMID 29774234Read ↗

Tpz1TPP1 SUMOylation reveals evolutionary conservation of SUMO‐dependent Stn1 telomere associationSemantic proximity Read ↗

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Conditional deletion of human STN1 leads to telomere dysfunction and telomerase-dependent genome instability and proliferation defectsSemantic proximity Read ↗

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Evolution of CST function in telomere maintenanceSemantic proximity Read ↗

CTC1 OB-B interaction with TPP1 terminates telomerase and prevents telomere overextension.Semantic proximity Read ↗

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Human TEN1 Maintains Telomere Integrity and Functions in Genome-wide Replication RestartSemantic proximity Read ↗

Overlapping open reading frames strongly reduce human and yeast STN1 gene expression and affect telomere function.Semantic proximity Read ↗

Human CST Has Independent Functions during Telomere Duplex Replication and C-Strand Fill-InSemantic proximity Read ↗

CTC1-mediated C-strand fill-in is an essential step in telomere length maintenanceSemantic proximity Read ↗

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