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Article

Role of STN1 and DNA polymerase α in telomere stability and genome-wide replication in Arabidopsis.

PLoS genetics - 1 Oct 2014

Derboven Elisa, Ekker Heinz, Kusenda Branislav, Bulankova Petra, Riha Karel

Abstract excerpt

The CST (Cdc13/CTC1-STN1-TEN1) complex was proposed to have evolved kingdom specific roles in telomere capping and replication. To shed light on its evolutionary conserved function, we examined the effect of STN1 dysfunction on telomere structure in plants. STN1 inactivation in Arabidopsis leads to a progressive loss of telomeric DNA and the onset of telomeric defects depends on the initial telomere size. While...

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Topics

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Share to Chromosomal Proteins, Non-Histone
Share to DNA Polymerase I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Replication

Share to Exodeoxyribonucleases

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Source

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Identifiers

PMID: 25299252
DOI: 10.1371/journal.pgen.1004682
PMCID: PMC4191939

Genes

STN1
CTC1
EXO1
TEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Research trail→

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Role of STN1 and DNA polymerase α in telomere stability and genome-wide replication in Arabidopsis.PMID 25299252Read ↗

Conserved telomere maintenance component 1 interacts with STN1 and maintains chromosome ends in higher eukaryotes.Semantic proximity Read ↗

MERISTEM DISORGANIZATION1 encodes TEN1, an essential telomere protein that modulates telomerase processivity in Arabidopsis.Semantic proximity Read ↗

Conditional deletion of human STN1 leads to telomere dysfunction and telomerase-dependent genome instability and proliferation defectsSemantic proximity Read ↗

Human CST Has Independent Functions during Telomere Duplex Replication and C-Strand Fill-InSemantic proximity Read ↗

The fission yeast Stn1-Ten1 complex limits telomerase activity via its SUMO-interacting motif and promotes telomeres replication.Semantic proximity Read ↗

CTC1-mediated C-strand fill-in is an essential step in telomere length maintenanceSemantic proximity Read ↗

Distinct roles for yeast Stn1 in telomere capping and telomerase inhibition.Semantic proximity Read ↗

Human TEN1 Maintains Telomere Integrity and Functions in Genome-wide Replication RestartSemantic proximity Read ↗

Evolution of CST function in telomere maintenanceSemantic proximity Read ↗

Emerging roles of CST in maintaining genome stability and human disease.Semantic proximity Read ↗

CTC1-STN1 terminates telomerase while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cellsSemantic proximity Read ↗

TEN1 is essential for CDC13-mediated telomere capping.Semantic proximity Read ↗

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