Article
Fission yeast Stn1 maintains stability of repetitive DNA at subtelomere and ribosomal DNA regions.
Nucleic acids research - 11 Oct 2021
Yamamoto Io, Nakaoka Hidenori, Takikawa Masahiro, Tashiro Sanki, Kanoh Junko, Miyoshi Tomoichiro, Ishikawa Fuyuki
Abstract excerpt
Telomere binding protein Stn1 forms the CST (Cdc13/CTC1-STN1-TEN1) complex in budding yeast and mammals. Likewise, fission yeast Stn1 and Ten1 form a complex indispensable for telomere protection. We have previously reported that stn1-1, a high-temperature sensitive mutant, rapidly loses telomere DNA at the restrictive temperature due to frequent failure of replication fork progression at telomeres and...
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