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Article

Est1 protects telomeres and inhibits subtelomeric y'-element recombination.

Molecular and cellular biology - 1 Mar 2011

Tong Xia-Jing, Li Qian-Jin, Duan Yi-Min, Liu Ning-Ning, Zhang Ming-Liang, Zhou Jin-Qiu

Abstract excerpt

In the budding yeast Saccharomyces cerevisiae, the structure and function of telomeres are maintained by binding proteins, such as Cdc13-Stn1-Ten1 (CST), Yku, and the telomerase complex. Like CST and Yku, telomerase also plays a role in telomere protection or capping. Unlike CST and Yku, however, the underlying molecular mechanism of telomerase-mediated telomere protection remains unclear. In this study, we...

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Identifiers

PMID: 21220516
DOI: 10.1128/MCB.00831-10
PMCID: PMC3067898

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Est1 protects telomeres and inhibits subtelomeric y'-element recombination.PMID 21220516Read ↗

The Est1 subunit of yeast telomerase binds the Tlc1 telomerase RNA.Semantic proximity Read ↗

Cdc13 cooperates with the yeast Ku proteins and Stn1 to regulate telomerase recruitment.Semantic proximity Read ↗

EXO1 contributes to telomere maintenance in both telomerase-proficient and telomerase-deficient Saccharomyces cerevisiae.Semantic proximity Read ↗

Evolution of CST function in telomere maintenanceSemantic proximity Read ↗

A yeast telomerase complex containing the Est1 recruitment protein is assembled early in the cell cycle.Semantic proximity Read ↗

Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13.Semantic proximity Read ↗

Distinct roles for yeast Stn1 in telomere capping and telomerase inhibition.Semantic proximity Read ↗

The telomeric Cdc13 protein interacts directly with the telomerase subunit Est1 to bring it to telomeric DNA ends in vitro.Semantic proximity Read ↗

The fission yeast Stn1-Ten1 complex limits telomerase activity via its SUMO-interacting motif and promotes telomeres replication.Semantic proximity Read ↗

Conserved telomere maintenance component 1 interacts with STN1 and maintains chromosome ends in higher eukaryotes.Semantic proximity Read ↗

A second essential function of the Est1-binding arm of yeast telomerase RNA.Semantic proximity Read ↗

Protection of telomeres by a conserved Stn1–Ten1 complexSemantic proximity Read ↗

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