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Article

Human CST Has Independent Functions during Telomere Duplex Replication and C-Strand Fill-In

1 Nov 2012

Abstract excerpt

Human CST (CTC1-STN1-TEN1) is an RPA-like complex that is needed for efficient replication through the telomere duplex and genome-wide replication restart after fork stalling. Here, we show that STN1/CST has a second function in telomere replication during G-overhang maturation. Analysis of overhang structure after STN1 depletion revealed normal kinetics for telomerase-mediated extension in S phase but a delay in...

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Identifiers

PMID: 23142664
DOI: 10.1016/j.celrep.2012.10.007

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Related research

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Research trail→

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Human CST Has Independent Functions during Telomere Duplex Replication and C-Strand Fill-InPMID 23142664Read ↗

CTC1-mediated C-strand fill-in is an essential step in telomere length maintenanceSemantic proximity Read ↗

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Mammalian CST averts replication failure by preventing G-quadruplex accumulationSemantic proximity Read ↗

Human TEN1 Maintains Telomere Integrity and Functions in Genome-wide Replication RestartSemantic proximity Read ↗

Conditional deletion of human STN1 leads to telomere dysfunction and telomerase-dependent genome instability and proliferation defectsSemantic proximity Read ↗

Human Stn1 protects telomere integrity by promoting efficient lagging-strand synthesis at telomeres and mediating C-strand fill-inSemantic proximity Read ↗

CTC1-STN1 terminates telomerase while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cellsSemantic proximity Read ↗

Reconstitution of a telomeric replicon organized by CSTSemantic proximity Read ↗

Human CST Facilitates Genome-wide RAD51 Recruitment to GC-Rich Repetitive Sequences in Response to Replication StressSemantic proximity Read ↗

Evolution of CST function in telomere maintenanceSemantic proximity Read ↗

Human CST promotes telomere duplex replication and general replication restart after fork stallingSemantic proximity Read ↗

CTC1 OB-B interaction with TPP1 terminates telomerase and prevents telomere overextension.Semantic proximity Read ↗

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