Article
VDR in Osteoblast-Lineage Cells Primarily Mediates Vitamin D Treatment-Induced Increase in Bone Mass by Suppressing Bone Resorption.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jun 2017
Nakamichi Yuko, Udagawa Nobuyuki, Horibe Kanji, Mizoguchi Toshihide, Yamamoto Yoko, Nakamura Takashi, Hosoya Akihiro, Kato Shigeaki, Suda Tatsuo, Takahashi Naoyuki
Abstract excerpt
Long-term treatment with active vitamin D [1α,25(OH)2 D3 ] and its derivatives is effective for increasing bone mass in patients with primary and secondary osteoporosis. Derivatives of 1α,25(OH)2 D3 , including eldecalcitol (ELD), exert their actions through the vitamin D receptor (VDR). ELD is more resistant to metabolic degradation than 1α,25(OH)2 D3 . It is reported that ELD treatment causes a net increase in...
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