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Article

Postnatal Skeletal Deletion of Dickkopf-1 Increases Bone Formation and Bone Volume in Male and Female Mice, Despite Increased Sclerostin Expression.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Sept 2018

Colditz Juliane, Thiele Sylvia, Baschant Ulrike, Niehrs Christof, Bonewald Lynda F, Hofbauer Lorenz C, Rauner Martina

Abstract excerpt

The Wnt antagonist Dickkopf-1 (Dkk1) is a negative regulator of osteoblast function and bone mass. However, because of the lack of appropriate models, many aspects of its role in the regulation of postnatal bone turnover and its cellular source have remained unknown. In this study, we deleted Dkk1 postnatally and in different cell types using various Cre-drivers (Rosa26-ERT2-Cre, Osx-cre, Dmp1-Cre) and assessed...

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PMID: 29734465
DOI: 10.1002/jbmr.3463

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