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Defective autophagy in osteoblasts induces endoplasmic reticulum stress and causes remarkable bone loss.

Autophagy - 1 Jan 2018

Li Huixia, Li Danhui, Ma Zhengmin, Qian Zhuang, Kang Xiaomin, Jin Xinxin, Li Fang, Wang Xinluan, Chen Qian, Sun Hongzhi, Wu Shufang

Abstract excerpt

Macroautophagy/autophagy is a highly regulated process involved in the turnover of cytosolic components, however its pivotal role in maintenance of bone homeostasis remains elusive. In the present study, we investigated the direct role of ATG7 (autophagy related 7) during developmental and remodeling stages in vivo using osteoblast-specific Atg7 conditional knockout (cKO) mice. Atg7 cKO mice exhibited a reduced...

Topics

Animals
Apoptosis
Autophagy
Autophagy-Related Protein 7
Biomarkers
Bone Resorption
Bone and Bones
Calcification, Physiologic
Cell Differentiation
Cells, Cultured
Endoplasmic Reticulum Stress

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Deletion

Mice, Knockout

Organ Size

Osteoblasts

Osteogenesis

Phenotype

Phenylbutyrates

Source

Open in PubMed Open full text

Identifiers

PMID: 29962255
DOI: 10.1080/15548627.2018.1483807
PMCID: PMC6135623

Genes

ATG7
DDIT3
MAPK8
SMAD1
TNFSF11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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