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Article

Osteoprotective Effects of Estrogen in the Maxillary Bone Depend on ERα.

Journal of dental research - 1 Jun 2016

Macari S, Ajay Sharma L, Wyatt A, Knowles P, Szawka R E, Garlet G P, Grattan D R, Dias G J, Silva T A

Abstract excerpt

Estrogen deficiency results in disruption of maxillary alveolar bone microarchitecture. Most of the actions of estrogen in long bones occur via estrogen receptor α (ERα). However, the function of ERα in the maxillary bone has not been defined. We aimed to investigate the role and underlying mechanisms of ERα in the physiological and mechanically induced alveolar bone remodeling in female and male mice. Wild-type...

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PMID: 26917440
DOI: 10.1177/0022034516633154

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TNF

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