Article
VDR haploinsufficiency impacts body composition and skeletal acquisition in a gender-specific manner.
Calcified tissue international - 1 Sept 2011
de Paula Francisco J A, Dick-de-Paula Ingrid, Bornstein Sheila, Rostama Bahman, Le Phuong, Lotinun Sutada, Baron Roland, Rosen Clifford J
Abstract excerpt
The vitamin D receptor (VDR) is crucial for virtually all of vitamin D's actions and is thought to be ubiquitously expressed. We hypothesized that disruption of one allele of the VDR gene would impact bone development and would have metabolic consequences. Body composition and bone mass (BMD) in VDR heterozygous (VDR HET) mice were compared to those obtained in male and female VDR KO and WT mice at 8 weeks of...
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