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Article

Calcium sensing receptor‐dependent and receptor‐independent activation of osteoblast replication and survival by strontium ranelate

28 Jan 2009

Abstract excerpt

Age-related osteopenia is characterized by a negative balance between bone resorption and formation. The anti-osteoporotic drug strontium ranelate was found to reduce bone resorption and to promote bone formation. Here, we investigated the implication of the calcium-sensing receptor (CaSR) in the response to strontium ranelate using osteoblasts from CaSR knockout [CaSR(-/-)] and wild-type [CaSR(+/+)] mice. We...

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PMID: 20141614
DOI: 10.1111/j.1582-4934.2008.00673.x

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