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Article

Nongenomic effects of 1α,25-dihydroxyvitamin D3 on cartilage formation deduced from comparisons between Cyp27b1 and Vdr knockout mice.

Biochemical and biophysical research communications - 29 Jan 2017

Hirota Yoshihisa, Nakagawa Kimie, Mimatsu Shino, Sawada Natsumi, Sakaki Toshiyuki, Kubodera Noboru, Kamao Maya, Tsugawa Naoko, Suhara Yoshitomo, Okano Toshio

Abstract excerpt

The active form of vitamin D, 1α,25-dihydroxyvitamin D3 (1α,25D3), plays an important role in the maintenance of calcium (Ca) homeostasis, bone formation, and cell proliferation and differentiation via nuclear vitamin D receptor (VDR). It is formed by the hydroxylation of vitamin D at the 1α position by 25-hydroxyvitamin D 1α-hydroxylase (CYP27B1) in the kidney. However, Cyp27b1-/- mice, deficient in CYP27B1, and...

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Share to 25-Hydroxyvitamin D3 1-alpha-Hydroxylase
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Identifiers

PMID: 28025137
DOI: 10.1016/j.bbrc.2016.12.139

Genes

VDR

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