Article
A thermostable d-polymerase for mirror-image PCR.
Nucleic acids research - 20 Apr 2017
Pech Andreas, Achenbach John, Jahnz Michael, Schülzchen Simone, Jarosch Florian, Bordusa Frank, Klussmann Sven
Abstract excerpt
Biological evolution resulted in a homochiral world in which nucleic acids consist exclusively of d-nucleotides and proteins made by ribosomal translation of l-amino acids. From the perspective of synthetic biology, however, particularly anabolic enzymes that could build the mirror-image counterparts of biological macromolecules such as l-DNA or l-RNA are lacking. Based on a convergent synthesis strategy, we have...
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