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Article

Investigating the role of the little finger domain of Y-family DNA polymerases in low fidelity synthesis and translesion replication.

The Journal of biological chemistry - 30 Jul 2004

Boudsocq François, Kokoska Robert J, Plosky Brian S, Vaisman Alexandra, Ling Hong, Kunkel Thomas A, Yang Wei, Woodgate Roger

Abstract excerpt

Dpo4 and Dbh are Y-family polymerases that originate from two closely related strains of Sulfolobaceae. Quite surprisingly, however, the two polymerases exhibit different enzymatic properties in vitro. For example, Dpo4 can replicate past a variety of DNA lesions, yet Dbh does so with a much lower efficiency. When replicating undamaged DNA, Dpo4 is prone to make base pair substitutions, whereas Dbh predominantly...

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PMID: 15155753
DOI: 10.1074/jbc.M405249200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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