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Article

Structural basis for TNA synthesis by an engineered TNA polymerase.

Nature communications - 27 Nov 2017

Chim Nicholas, Shi Changhua, Sau Sujay P, Nikoomanzar Ali, Chaput John C

Abstract excerpt

Darwinian evolution experiments carried out on xeno-nucleic acid (XNA) polymers require engineered polymerases that can faithfully and efficiently copy genetic information back and forth between DNA and XNA. However, current XNA polymerases function with inferior activity relative to their natural counterparts. Here, we report five X-ray crystal structures that illustrate the pathway by which α-(L)-threofuranosyl...

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Identifiers

PMID: 29180809
DOI: 10.1038/s41467-017-02014-0
PMCID: PMC5703726

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