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Article

Sloppy bypass of an abasic lesion catalyzed by a Y-family DNA polymerase.

The Journal of biological chemistry - 16 Mar 2007

Fiala Kevin A, Suo Zucai

Abstract excerpt

DNA damage that eludes cellular repair pathways can arrest the replication machinery and stall the cell cycle. However, this damage can be bypassed by the Y-family DNA polymerases. Here, Dpo4, an archetypal Y-family member from the thermophilic Sulfolobus solfataricus, was used to extend our kinetic studies of the bypass of an abasic site, one of the most mutagenic and ubiquitous cellular lesions. A short...

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Source

Identifiers

PMID: 17234630
DOI: 10.1074/jbc.M610719200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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