Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolution of an Enzyme from a Noncatalytic Nucleic Acid Sequence.

Scientific reports - 19 Jun 2015

Gysbers Rachel, Tram Kha, Gu Jimmy, Li Yingfu

Abstract excerpt

The mechanism by which enzymes arose from both abiotic and biological worlds remains an unsolved natural mystery. We postulate that an enzyme can emerge from any sequence of any functional polymer under permissive evolutionary conditions. To support this premise, we have arbitrarily chosen a 50-nucleotide DNA fragment encoding for the Bos taurus (cattle) albumin mRNA and subjected it to test-tube evolution to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Evolution
Share to Cattle
Share to DNA, Catalytic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzymes

Share to Evolution, Molecular

Share to High-Throughput Screening Assays

Share to Nucleic Acid Conformation

Source

Open in PubMed Open full text

Identifiers

PMID: 26091540
DOI: 10.1038/srep11405
PMCID: PMC4473686

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolution of an Enzyme from a Noncatalytic Nucleic Acid Sequence.PMID 26091540Read ↗

Getting a DNA to do an RNA's job.Semantic proximity Read ↗

The prebiotic evolutionary advantage of transferring genetic information from RNA to DNA.Semantic proximity Read ↗

Reconstructed evolutionary adaptive paths give polymerases accepting reversible terminators for sequencing and SNP detection.Semantic proximity Read ↗

Chemical evolution of an autonomous DNAzyme with allele-specific gene silencing activity.Semantic proximity Read ↗

Improving Polymerase Activity with Unnatural Substrates by Sampling Mutations in Homologous Protein Architectures.Semantic proximity Read ↗

Prebiotically plausible mechanisms increase compositional diversity of nucleic acid sequences.Semantic proximity Read ↗

Witnessing the structural evolution of an RNA enzyme.Semantic proximity Read ↗

Diminishing returns and tradeoffs constrain the laboratory optimization of an enzyme.Semantic proximity Read ↗

Evolutionary dynamics of enzymes.Semantic proximity Read ↗

Systematic molecular evolution enables robust biomolecule discovery.Semantic proximity Read ↗

Evolutionary origin of RNA editing.Semantic proximity Read ↗

Molecular evolution of catalysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.