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Article

Kinetic basis of sugar selection by a Y-family DNA polymerase from Sulfolobus solfataricus P2.

Biochemistry - 30 Nov 2010

Sherrer Shanen M, Beyer David C, Xia Cynthia X, Fowler Jason D, Suo Zucai

Abstract excerpt

DNA polymerases use either a bulky active site residue or a backbone segment to select against ribonucleotides in order to faithfully replicate cellular genomes. Here, we demonstrated that an active site mutation (Y12A) within Sulfolobus solfataricus DNA polymerase IV (Dpo4) caused an average increase of 220-fold in matched ribonucleotide incorporation efficiency and an average decrease of 9-fold in correct...

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PMID: 20973506
DOI: 10.1021/bi101465n

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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