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Functional Comparison of Laboratory-Evolved XNA Polymerases for Synthetic Biology.

ACS synthetic biology - 18 Jun 2021

Medina Esau, Yik Eric J, Herdewijn Piet, Chaput John C

Abstract excerpt

Artificial genetic polymers (XNAs) have enormous potential as new materials for synthetic biology, biotechnology, and molecular medicine; yet, very little is known about the biochemical properties of XNA polymerases that have been developed to synthesize and reverse-transcribe XNA polymers. Here, we compare the substrate specificity, thermal stability, reverse transcriptase activity, and fidelity of...

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DNA-Directed DNA Polymerase
Laboratories
Polymers
Protein Engineering
Protein Folding

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Stability

Reverse Transcription

Synthetic Biology

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PMID: 34029459
DOI: 10.1021/acssynbio.1c00048

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