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Article

Sequence-Specific Regulation of Endocytic Lifetimes Modulates Arrestin-Mediated Signaling at the µ Opioid Receptor.

Molecular pharmacology - 1 Apr 2017

Weinberg Zara Y, Zajac Amanda S, Phan Tiffany, Shiwarski Daniel J, Puthenveedu Manojkumar A

Abstract excerpt

Functional selectivity at the µ opioid receptor (µR), a prototypical G-protein-coupled receptor that is a physiologically relevant target for endogenous opioid neurotransmitters and analgesics, has been a major focus for drug discovery in the recent past. Functional selectivity is a cumulative effect of the magnitudes of individual signaling pathways, e.g., the Gαi-mediated and the arrestin-mediated pathways for...

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Identifiers

PMID: 28153854
DOI: 10.1124/mol.116.106633
PMCID: PMC5363713

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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