Article
Unraveling G protein-coupled receptor endocytosis pathways using real-time monitoring of agonist-promoted interaction between beta-arrestins and AP-2.
The Journal of biological chemistry - 5 Oct 2007
Hamdan Fadi F, Rochdi Moulay Driss, Breton Billy, Fessart Delphine, Michaud Douce E, Charest Pascale G, Laporte Stéphane A, Bouvier Michel
Abstract excerpt
The most widely studied pathway underlying agonist-promoted internalization of G protein-coupled receptors (GPCRs) involves beta-arrestin and clathrin-coated pits. However, both beta-arrestin- and clathrin-independent processes have also been reported. Classically, the endocytic routes are characterized using pharmacological inhibitors and various dominant negative mutants, resulting sometimes in conflicting...
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