Article
Heptahelical terpsichory. Who calls the tune?
Journal of receptor and signal transduction research - 1 Jan 2008
Gesty-Palmer Diane, Luttrell Louis M
Abstract excerpt
The discovery that arrestins can function as ligand-regulated signaling scaffolds has revealed a previously unappreciated level of complexity in G protein-coupled receptor (GPCR) signal transduction. Because arrestin-bound GPCRs are uncoupled from G proteins, arrestin binding can be viewed as switching receptors between two temporally and spatially distinct signaling modes. Recent work has established two factors...
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