Article
Receptor/beta-arrestin complex formation and the differential trafficking and resensitization of beta2-adrenergic and angiotensin II type 1A receptors.
Molecular endocrinology (Baltimore, Md.) - 1 Dec 2000
Anborgh P H, Seachrist J L, Dale L B, Ferguson S S
Abstract excerpt
Beta-arrestins target G protein-coupled receptors (GPCRs) for endocytosis via clathrin-coated vesicles. Beta-arrestins also become detectable on endocytic vesicles in response to angiotensin II type 1A receptor (AT1AR), but not beta2-adrenergic receptor (beta2AR), activation. The carboxyl-terminal tails of these receptors contribute directly to this phenotype, since a beta2AR bearing the AT1AR tail acquired the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
