Article
Novel HBsAg mutations correlate with hepatocellular carcinoma, hamper HBsAg secretion and promote cell proliferation in vitro.
Oncotarget - 28 Feb 2017
Salpini Romina, Surdo Matteo, Warner Nadia, Cortese Maria Francesca, Colledge Danny, Soppe Sally, Bellocchi Maria Concetta, Armenia Daniele, Carioti Luca, Continenza Fabio, Di Carlo Domenico, Saccomandi Patrizia, Mirabelli Carmen, Pollicita Michela, Longo Roberta, Romano Sara, Cappiello Giuseppina, Spanò Alberto, Trimoulet Pascale, Fleury Herve, Vecchiet Jacopo, Iapadre Nerio, Barlattani Angelo, Bertoli Ada, Mari Terenzio, Pasquazzi Caterina, Missale Gabriele, Sarrecchia Cesare, Orecchini Elisa, Michienzi Alessandro, Andreoni Massimo, Francioso Simona, Angelico Mario, Verheyen Jens, Ceccherini-Silberstein Francesca, Locarnini Stephen, Perno Carlo Federico, Svicher Valentina
Abstract excerpt
BACKGROUND: An impaired HBsAg-secretion can increase HBV oncogenic-properties. Here, we investigate genetic-determinants in HBsAg correlated with HBV-induced hepatocellular carcinoma (HCC), and their impact on HBsAg-secretion and cell-proliferation. METHODS: This study included 128 chronically HBV-infected patients: 23 with HCC (73.9% D; 26.1% A HBV-genotype), and 105 without cirrhosis/HCC (72.4% D, 27.6% A) as...
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