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Identification and characteristics of mutations promoting occult HBV infection by ultrasensitive HBsAg assay.

Journal of clinical microbiology - 14 May 2025

Song Shi, Su Qian, Yan Ying, Ji Huimin, Sun Huizhen, Feng Kaihao, Nuermaimaiti Abudulimutailipu, Halemubieke Shana, Mei Ling, Liu Xinru, Lu Zhuoqun, Chang Le, Wang Lunan

Abstract excerpt

The significance of occult hepatitis B virus (HBV) infection (OBI) has been increasingly recognized while the underlying mechanisms remain incompletely understood. This study aimed to identify high-frequency OBI-related mutations in HBV surface antigen (HBsAg)-negative samples tested by the ultrasensitive Lumipulse G HBsAg-Quant assay. OBI samples were collected from 32 blood establishments across 14 provinces in...

Topics

Humans
Hepatitis B Surface Antigens
Hepatitis B virus
Hepatitis B
Mutation
Genotype
China
Sensitivity and Specificity

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40162819
DOI: 10.1128/jcm.02071-24
PMCID: PMC12077177

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