Article
Specific mutations in the C-terminus domain of HBV surface antigen significantly correlate with low level of serum HBV-DNA in patients with chronic HBV infection.
The Journal of infection - 1 Mar 2015
Mirabelli Carmen, Surdo Matteo, Van Hemert Formijn, Lian Zhichao, Salpini Romina, Cento Valeria, Cortese Maria Francesca, Aragri Marianna, Pollicita Michela, Alteri Claudia, Bertoli Ada, Berkhout Ben, Micheli Valeria, Gubertini Guido, Santoro Maria Mercedes, Romano Sara, Visca Michela, Bernassola Martina, Longo Roberta, De Sanctis Giuseppe Maria, Trimoulet Pascal, Fleury Hervè, Marino Nicoletta, Mazzotta Francesco, Cappiello Giuseppina, Spanò Alberto, Sarrecchia Cesare, Zhang Jing Maria, Andreoni Massimo, Angelico Mario, Verheyen Jens, Perno Carlo Federico, Svicher Valentina
Abstract excerpt
BACKGROUND: To define HBsAg-mutations correlated with different serum HBV-DNA levels in HBV chronically-infected drug-naive patients. METHODS: This study included 187 patients stratified into the following ranges of serum HBV-DNA:12-2000 IU/ml, 2000-100,000 IU/ml, and >100,000 IU/ml. HBsAg-mutations were associated with HBV-DNA levels by applying a Bayesian-Partitional-Model and Fisher-exact test. Mutant and...
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