Article
Key mutations in the C-terminus of the HBV surface glycoprotein correlate with lower HBsAg levels in vivo, hinder HBsAg secretion in vitro and reduce HBsAg structural stability in the setting of HBeAg-negative chronic HBV genotype-D infection.
Emerging microbes & infections - 1 Dec 2020
Salpini Romina, Battisti Arianna, Piermatteo Lorenzo, Carioti Luca, Anastasiou Olympia E, Gill Upkar S, Di Carlo Domenico, Colagrossi Luna, Duca Leonardo, Bertoli Ada, La Rosa Katia Yu, Fabeni Lavinia, Iuvara Alessandra, Malagnino Vincenzo, Cerva Carlotta, Lichtner Miriam, Mastroianni Claudio M, De Sanctis Giuseppe Maria, Paoloni Maurizio, Marignani Massimo, Pasquazzi Caterina, Iapadre Nerio, Parruti Giustino, Vecchiet Jacopo, Sarmati Loredana, Andreoni Massimo, Angelico Mario, Grelli Sandro, T Kennedy Patrick, Verheyen Jens, Aquaro Stefano, Silberstein Francesca Ceccherini, Perno Carlo Federico, Svicher Valentina
Abstract excerpt
Increasing evidences suggest that HBsAg-production varies across HBV-genotypes. HBsAg C-terminus plays a crucial role for HBsAg-secretion. Here, we evaluate HBsAg-levels in different HBV-genotypes in HBeAg-negative chronic infection, the correlation of specific mutations in HBsAg C-terminus with HBsAg-levels in-vivo, their impact on HBsAg-secretion in-vitro and on structural stability in-silico.HBsAg-levels were...
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