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Article

Effects of amino acid substitutions in hepatitis B virus surface protein on virion secretion, antigenicity, HBsAg and viral DNA.

Journal of hepatology - 1 Feb 2017

Xiang Kuan-Hui, Michailidis Eleftherios, Ding Hai, Peng Ya-Qin, Su Ming-Ze, Li Yao, Liu Xue-En, Dao Thi Viet Loan, Wu Xian-Fang, Schneider William M, Rice Charles M, Zhuang Hui, Li Tong

Abstract excerpt

BACKGROUND & AIMS: As important virological markers, serum hepatitis B surface antigen (HBsAg) and hepatitis B virus (HBV) DNA levels show large fluctuations among chronic hepatitis B patients. The aim of this study was to reveal the potential impact and mechanisms of amino acid substitutions in small hepatitis B surface proteins (SHBs) on serum HBsAg and HBV DNA levels. METHODS: Serum samples from 230 untreated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27650283
DOI: 10.1016/j.jhep.2016.09.005
PMCID: PMC5523976

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