The sV184A Variant in HBsAg Specific to HBV Subgenotype C2 Leads to Enhanced Viral Replication and Apoptotic Cell Death Induced by PERK-eIF2α-CHOP-Mediated ER Stress.

doi:10.1002/jmv.70253

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The sV184A Variant in HBsAg Specific to HBV Subgenotype C2 Leads to Enhanced Viral Replication and Apoptotic Cell Death Induced by PERK-eIF2α-CHOP-Mediated ER Stress.

Journal of medical virology - 1 Feb 2025

Choi Yu-Min, Kim Dong Hyun, Cho Eun Ju, Kim Ziyun, Jang Junghwa, Kim Hyunsoo, Yu Su Jong, Kim Bum-Joon

Abstract excerpt

HBV genotype C, particularly subgenotype C2, is associated with an elevated risk of HCC and aggressive disease activity. We previously identified a nonsynonymous sV184A variant in the HBsAg region, predominantly in HBV subgenotype C2. This study investigates the mechanistic role of the sV184A variant in promoting liver disease progression. Analysis of 109 chronically HBV-infected patients revealed that the sV184A...

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Topics

Humans
Endoplasmic Reticulum Stress
Virus Replication
Hepatitis B virus
Hepatitis B Surface Antigens

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Apoptosis

Transcription Factor CHOP

eIF-2 Kinase

Genotype

Eukaryotic Initiation Factor-2

Hepatitis B, Chronic

Male

Female

Animals

Middle Aged

DNA, Viral

Source

Open in PubMed

Identifiers

PMID: 39977392
DOI: 10.1002/jmv.70253

Genes

Provenance

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