Article
Novel HBsAg markers tightly correlate with occult HBV infection and strongly affect HBsAg detection.
Antiviral research - 1 Jan 2012
Svicher Valentina, Cento Valeria, Bernassola Martina, Neumann-Fraune Maria, Van Hemert Formijn, Chen Mengjie, Salpini Romina, Liu Chang, Longo Roberta, Visca Michela, Romano Sara, Micheli Valeria, Bertoli Ada, Gori Caterina, Ceccherini-Silberstein Francesca, Sarrecchia Cesare, Andreoni Massimo, Angelico Mario, Ursitti Antonella, Spanò Alberto, Zhang Jing Maria, Verheyen Jens, Cappiello Giuseppina, Perno Carlo Federico
Abstract excerpt
Occult HBV infection (OBI) is a threat for the safety of blood-supply, and has been associated with the onset of HBV-related hepatocellular carcinoma and lymphomagenesis. Nevertheless, genetic markers in HBsAg (particularly in D-genotype, the most common in Europe) significantly associated with OBI in vivo are missing. Thus, the goal of this study is to define: (i) prevalence and clinical profile of OBI among...
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