Article
Unexpected rise in the circulation of complex HBV variants enriched of HBsAg vaccine-escape mutations in HBV genotype-D: potential impact on HBsAg detection/quantification and vaccination strategies.
Emerging microbes & infections - 1 Dec 2023
Piermatteo Lorenzo, D'Anna Stefano, Bertoli Ada, Bellocchi Maria, Carioti Luca, Fabeni Lavinia, Alkhatib Mohammad, Frazia Simone La, Lichtner Miriam, Mastroianni Claudio, Sanctis Giuseppe De, Marignani Massimo, Pasquazzi Caterina, Iapadre Nerio, Parruti Giustino, Cappiello Giuseppina, Vecchiet Jacopo, Malagnino Vincenzo, Grelli Sandro, Ceccherini-Silbertein Francesca, Andreoni Massimo, Sarmati Loredana, Svicher Valentina, Salpini Romina
Abstract excerpt
Specific HBsAg mutations are known to hamper HBsAg recognition by neutralizing antibodies thus challenging HBV-vaccination efficacy. Nevertheless, information on their impact and spreading over time is limited. Here, we characterize the circulation of vaccine-escape mutations from 2005 to 2019 and their correlation with virological parameters in a large cohort of patients infected with HBV genotype-D (N = 947),...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.