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Analysis of the Physicochemical Properties, Replication and Pathophysiology of a Massively Glycosylated Hepatitis B Virus HBsAg Escape Mutant.

Viruses - 22 Nov 2021

Hossain Md Golzar, Suwanmanee Yadarat, Du Kaili, Ueda Keiji

Abstract excerpt

Mutations in HBsAg, the surface antigen of the hepatitis B virus (HBV), might affect the serum HBV DNA level of HBV-infected patients, since the reverse transcriptase (RT) domain of HBV polymerase overlaps with the HBsAg-coding region. We previously identified a diagnostic escape mutant (W3S) HBV that produces massively glycosylated HBsAg. In this study, we constructed an HBV-producing vector that expresses W3S...

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Glycosylation
Hep G2 Cells
Hepatitis B
Hepatitis B Surface Antigens
Hepatitis B virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Virus Replication

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PMID: 34835134
DOI: 10.3390/v13112328
PMCID: PMC8622389

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