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Article

Pre-S mutations of hepatitis B virus affect genome replication and expression of surface antigens.

Journal of gastroenterology and hepatology - 1 Apr 2014

Kim Beom Kyung, Choi Sung Hoon, Ahn Sung Hyun, Chung Ae Ri, Park Yong Kwang, Han Kwang-Hyub, Kim Seungtaek, Kim Hyon-Suk, Park Jeon Han, Kim Kyung Sik, Lee Hee Seung, Cho Yong Sang, Kim Kyun-Hwan, Ahn Sang Hoon

Abstract excerpt

BACKGROUNDS AND AIMS: In chronic hepatitis B virus (HBV) infection, quantitative HBV surface antigen (qHBsAg) is useful for monitoring viral replication and treatment responses. We aimed to determine whether pre-S mutations have any effect on circulating qHBsAg. METHODS: Plasmids expressing 1–8 amino acid deletion in pre-S1 ("pre-S1Δ1-8") and 3-25 amino acid deletion in pre-S2 ("pre-S2Δ3-25") were constructed. At...

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Share to Gene Expression Regulation, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24783251
DOI: 10.1111/jgh.12415

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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