Article
Clonal evolution in relapsed NPM1-mutated acute myeloid leukemia.
Blood - 4 Jul 2013
Krönke Jan, Bullinger Lars, Teleanu Veronica, Tschürtz Florian, Gaidzik Verena I, Kühn Michael W M, Rücker Frank G, Holzmann Karlheinz, Paschka Peter, Kapp-Schwörer Silke, Späth Daniela, Kindler Thomas, Schittenhelm Marcus, Krauter Jürgen, Ganser Arnold, Göhring Gudrun, Schlegelberger Brigitte, Schlenk Richard F, Döhner Hartmut, Döhner Konstanze
Abstract excerpt
Mutations in the nucleophosmin 1 (NPM1) gene are considered a founder event in the pathogenesis of acute myeloid leukemia (AML). To address the role of clonal evolution in relapsed NPM1-mutated (NPM1mut) AML, we applied high-resolution, genome-wide, single-nucleotide polymorphism array profiling to detect copy number alterations (CNAs) and uniparental disomies (UPDs) and performed comprehensive gene mutation...
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