Article
Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia.
Blood - 4 Aug 2016
Metzeler Klaus H, Herold Tobias, Rothenberg-Thurley Maja, Amler Susanne, Sauerland Maria C, Görlich Dennis, Schneider Stephanie, Konstandin Nikola P, Dufour Annika, Bräundl Kathrin, Ksienzyk Bianka, Zellmeier Evelyn, Hartmann Luise, Greif Philipp A, Fiegl Michael, Subklewe Marion, Bohlander Stefan K, Krug Utz, Faldum Andreas, Berdel Wolfgang E, Wörmann Bernhard, Büchner Thomas, Hiddemann Wolfgang, Braess Jan, Spiekermann Karsten
Abstract excerpt
The clinical and prognostic relevance of many recently identified driver gene mutations in adult acute myeloid leukemia (AML) is poorly defined. We sequenced the coding regions or hotspot areas of 68 recurrently mutated genes in a cohort of 664 patients aged 18 to 86 years treated on 2 phase 3 trials of the German AML Cooperative Group (AMLCG). The median number of 4 mutations per patient varied according to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.