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Discovery of Rare Haplotypes by Typing Millions of Single-Molecules with Bead Emulsion Haplotyping (BEH).

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2017

Palzenberger Elisabeth, Reinhardt Ronja, Muresan Leila, Palaoro Barbara, Tiemann-Boege Irene

Abstract excerpt

Characterizing polymorphisms on single molecules renders the phase of different alleles, and thus, haplotype information. Here, we describe a high-throughput method to genotype hundreds-of thousands single molecules in parallel using bead-emulsion haplotyping (BEH). Haplotyping via BEH is an emulsion-PCR-based method that was adapted to amplify multiple DNA fragments on paramagnetic, microscopic beads within a...

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PMID: 28138851
DOI: 10.1007/978-1-4939-6750-6_14

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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