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Article

Molecular haplotyping by linking emulsion PCR: analysis of paraoxonase 1 haplotypes and phenotypes.

Nucleic acids research - 1 Jan 2005

Wetmur James G, Kumar Madhu, Zhang Li, Palomeque Caroline, Wallenstein Sylvan, Chen Jia

Abstract excerpt

Linking emulsion PCR (LE-PCR) enables formation of minichromosomes preserving phase information of two polymorphic loci, hence the haplotype. Emulsion PCR confines two amplicons of two linked polymorphic sites on a single template molecule to one aqueous-phase droplet. Linking PCR uses biotinylated, overlapping linking primers to connect these amplicons in the droplet. After LE-PCR, unlinked amplicons are removed...

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Share to Aryldialkylphosphatase
Share to Haplotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymerase Chain Reaction

Share to Polymorphism, Genetic

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Share to Sequence Analysis, DNA

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Source

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Identifiers

PMID: 15886392
DOI: 10.1093/nar/gki556
PMCID: PMC1092276

Genes

PON1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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