Article

Ultra-accurate Genome Sequencing and Haplotyping of Single Human Cells

2017-05-08

Abstract excerpt

Accurate detection of variants and long-range haplotypes in genomes of single human cells remains very challenging. Common approaches require extensive in vitro amplification of genomes of individual cells using DNA polymerases and high-throughput short-read DNA sequencing. These approaches have two notable drawbacks. First, polymerase replication errors could generate tens of thousands of false positive calls pe...

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Literature Corpus work: 93e2b62e-1776-5980-91b3-697aaceb5e18
DOI: 10.1101/135384

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