Article
High-throughput haplotype determination over long distances by haplotype fusion PCR and ligation haplotyping.
Nature protocols - 1 Jan 2009
Turner Daniel J, Hurles Matthew E
Abstract excerpt
When combined with haplotype fusion PCR (HF-PCR), ligation haplotyping is a robust, high-throughput method for empirical determination of haplotypes, which can be applied to assaying both sequence and structural variation over long distances. Unlike alternative approaches to haplotype determination, such as allele-specific PCR and long PCR, HF-PCR and ligation haplotyping do not suffer from mispriming or...
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