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Article

Ultraaccurate genome sequencing and haplotyping of single human cells.

Proceedings of the National Academy of Sciences of the United States of America - 21 Nov 2017

Chu Wai Keung, Edge Peter, Lee Ho Suk, Bansal Vikas, Bafna Vineet, Huang Xiaohua, Zhang Kun

Abstract excerpt

Accurate detection of variants and long-range haplotypes in genomes of single human cells remains very challenging. Common approaches require extensive in vitro amplification of genomes of individual cells using DNA polymerases and high-throughput short-read DNA sequencing. These approaches have two notable drawbacks. First, polymerase replication errors could generate tens of thousands of false-positive calls...

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Identifiers

PMID: 29078313
DOI: 10.1073/pnas.1707609114
PMCID: PMC5703283

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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