Article
Transforming single DNA molecules into fluorescent magnetic particles for detection and enumeration of genetic variations.
Proceedings of the National Academy of Sciences of the United States of America - 22 Jul 2003
Dressman Devin, Yan Hai, Traverso Giovanni, Kinzler Kenneth W, Vogelstein Bert
Abstract excerpt
Many areas of biomedical research depend on the analysis of uncommon variations in individual genes or transcripts. Here we describe a method that can quantify such variation at a scale and ease heretofore unattainable. Each DNA molecule in a collection of such molecules is converted into a single magnetic particle to which thousands of copies of DNA identical in sequence to the original are bound. This...
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