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Article

Expanding the chemical space of polyketides through structure-guided mutagenesis of Vitis vinifera stilbene synthase.

Biochimie - 1 Aug 2015

Bhan Namita, Cress Brady F, Linhardt Robert J, Koffas Mattheos

Abstract excerpt

Several natural polyketides (PKs) have been associated with important pharmaceutical properties. Type III polyketide synthases (PKS) that generate aromatic PK polyketides have been studied extensively for their substrate promiscuity and product diversity. Stilbene synthase-like (STS) enzymes are unique in the type III PKS class as they possess a hydrogen bonding network, furnishing them with thioesterase-like...

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Identifiers

PMID: 26048582
DOI: 10.1016/j.biochi.2015.05.019

Genes

STS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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