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Article

Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates.

The Journal of biological chemistry - 22 Oct 2004

Austin Michael B, Izumikawa Miho, Bowman Marianne E, Udwary Daniel W, Ferrer Jean-Luc, Moore Bradley S, Noel Joseph P

Abstract excerpt

In bacteria, a structurally simple type III polyketide synthase (PKS) known as 1,3,6,8-tetrahydroxynaphthlene synthase (THNS) catalyzes the iterative condensation of five CoA-linked malonyl units to form a pentaketide intermediate. THNS subsequently catalyzes dual intramolecular Claisen and aldol condensations of this linear intermediate to produce the fused ring tetrahydroxynaphthalene (THN) skeleton. The type...

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PMID: 15265863
DOI: 10.1074/jbc.M406567200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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