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Article

Biochemistry-Guided Prediction of the Absolute Configuration of Fungal Reduced Polyketides.

Angewandte Chemie (International ed. in English) - 18 Oct 2021

Takino Junya, Kotani Akari, Ozaki Taro, Peng Wenquan, Yu Jie, Guo Yian, Mochizuki Susumu, Akimitsu Kazuya, Hashimoto Masaru, Ye Tao, Minami Atsushi, Oikawa Hideaki

Abstract excerpt

Highly reducing polyketide synthases (HR-PKSs) produce structurally diverse polyketides (PKs). The PK diversity is constructed by a variety of factors, including the β-keto processing, chain length, methylation pattern, and relative and absolute configurations of the substituents. We examined the stereochemical course of the PK processing for the synthesis of polyhydroxy PKs such as phialotides, phomenoic acid,...

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PMID: 34448341
DOI: 10.1002/anie.202110658

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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