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Article

Structural and biochemical analyses of regio- and stereospecificities observed in a type II polyketide ketoreductase.

Biochemistry - 31 May 2011

Javidpour Pouya, Korman Tyler Paz, Shakya Gaurav, Tsai Shiou-Chuan

Abstract excerpt

Type II polyketides include antibiotics such as tetracycline and chemotherapeutics such as daunorubicin. Type II polyketides are biosynthesized by the type II polyketide synthase (PKS) that consists of 5-10 stand-alone domains. In many type II PKSs, the type II ketoreductase (KR) specifically reduces the C9-carbonyl group. How the type II KR achieves such a high regiospecificity and the nature of...

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PMID: 21506596
DOI: 10.1021/bi200335f
PMCID: PMC3117988

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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