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Article

Molecular Basis for the Final Oxidative Rearrangement Steps in Chartreusin Biosynthesis.

Journal of the American Chemical Society - 29 Aug 2018

Wang Yi Shuang, Zhang Bo, Zhu Jiapeng, Yang Cheng Long, Guo Yu, Liu Cheng Li, Liu Fang, Huang Huiqin, Zhao Suwen, Liang Yong, Jiao Rui Hua, Tan Ren Xiang, Ge Hui Ming

Abstract excerpt

Oxidative rearrangements play key roles in introducing structural complexity and biological activities of natural products biosynthesized by type II polyketide synthases (PKSs). Chartreusin (1) is a potent antitumor polyketide that contains a unique rearranged pentacyclic aromatic bilactone aglycone derived from a type II PKS. Herein, we report an unprecedented dioxygenase, ChaP, that catalyzes the final α-pyrone...

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PMID: 30067334
DOI: 10.1021/jacs.8b06623

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