Article
Genome-Wide Analysis Identifies MEN1 and MAX Mutations and a Neuroendocrine-Like Molecular Heterogeneity in Quadruple WT GIST.
Molecular cancer research : MCR - 1 May 2017
Pantaleo Maria A, Urbini Milena, Indio Valentina, Ravegnini Gloria, Nannini Margherita, De Luca Matilde, Tarantino Giuseppe, Angelini Sabrina, Gronchi Alessandro, Vincenzi Bruno, Grignani Giovanni, Colombo Chiara, Fumagalli Elena, Gatto Lidia, Saponara Maristella, Ianni Manuela, Paterini Paola, Santini Donatella, Pirini M Giulia, Ceccarelli Claudio, Altimari Annalisa, Gruppioni Elisa, Renne Salvatore L, Collini Paola, Stacchiotti Silvia, Brandi Giovanni, Casali Paolo G, Pinna Antonio D, Astolfi Annalisa, Biasco Guido
Abstract excerpt
Quadruple wild-type (WT) gastrointestinal stromal tumor (GIST) is a genomic subgroup lacking KIT/PDGFRA/RAS pathway mutations, with an intact succinate dehydrogenase (SDH) complex. The aim of this work is to perform a wide comprehensive genomic study on quadruple WT GIST to improve the characterization of these patients. We selected 14 clinical cases of quadruple WT GIST, of which nine cases showed sufficient DNA...
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