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Article

What is New in Gastrointestinal Stromal Tumor?

Advances in anatomic pathology - 1 Sept 2017

Schaefer Inga-Marie, Mariño-Enríquez Adrián, Fletcher Jonathan A

Abstract excerpt

The classification "gastrointestinal stromal tumor" (GIST) became commonplace in the 1990s and since that time various advances have characterized the GIST lineage of origin, tyrosine kinase mutations, and mechanisms of response and resistance to targeted therapies. In addition to tyrosine kinase mutations and their constitutive activation of downstream signaling pathways, GISTs acquire a sequence of chromosomal...

Topics

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Chromosome Aberrations
Gastrointestinal Stromal Tumors
MAX gene
PDGFRA gene
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Invasiveness

Signal Transduction

Transcription Factors

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Open in PubMed Open full text

Identifiers

PMID: 28632504
DOI: 10.1097/PAP.0000000000000158
PMCID: PMC5608028

Genes

KIT
MAX
PDGFRA
ETV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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