Article
Molecular characterization of metastatic exon 11 mutant gastrointestinal stromal tumors (GIST) beyond KIT/PDGFRα genotype evaluated by next generation sequencing (NGS).
Oncotarget - 8 Dec 2015
Saponara Maristella, Urbini Milena, Astolfi Annalisa, Indio Valentina, Ercolani Giorgio, Del Gaudio Massimo, Santini Donatella, Pirini Maria Giulia, Fiorentino Michelangelo, Nannini Margherita, Lolli Cristian, Mandrioli Anna, Gatto Lidia, Brandi Giovanni, Biasco Guido, Pinna Antonio Daniele, Pantaleo Maria Abbondanza
Abstract excerpt
About 85% of GISTs are associated with KIT and PDGFRα gene mutations, which predict response to tyrosine kinase inhibitors. Although the outcomes in patients affected by GIST have dramatically improved, tumor progression control still remains a challenge. The aim of this study is the genomic characterization of individual metastatic KIT-exon 11-mutant GIST to identify additional aberrations and simultaneous...
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