Article
Genomic Study of Chinese Quadruple-negative GISTs Using Next-generation Sequencing Technology.
Applied immunohistochemistry & molecular morphology : AIMM - 1 Jan 2021
Wang Si, Sun Rui-Ze, Han Qiang, Wang Si-Yao, Wang En-Hua, Liu Yang
Abstract excerpt
PURPOSE: Approximately 10% of gastrointestinal stromal tumors (GISTs) are devoid of KIT, PDGFRA (platelet-derived growth factor-alpha), BRAF, and SDH alterations. The aim of this study was to characterize molecular drivers in Chinese patients with quadruple-negative GISTs. PATIENTS AND METHODS: In 1022 Chinese patients with GIST, mutations of KIT and PDGFRA were analyzed by direct sequencing. Of these mutations,...
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